Helicobacter pylori y enfermedades alérgicas en niños: un estudio de casos y controles
DOI:
https://doi.org/10.31698/ped.50032023004Palabras clave:
Alergias, Helicobacter pylori, historia familiar, niñosResumen
Introducción: En las dos últimas décadas, se ha explorado el rol de la infección por Helicobacter pylori en la génesis de las enfermedades alérgicas, obteniéndose datos que apoyan la idea de que podría jugar un papel importante en el desarrollo de la alergia.
Objetivo: Identificar la asociación entre Helicobacter pylori y enfermedades alérgicas.
Materiales y métodos: Estudio de casos y controles prospectivo realizado en la Clínica “Santa Cruz” (Barquisimeto, Estado Lara, Venezuela), entre junio 2022 y junio 2023, donde se compararon 65 niños con enfermedades alérgicas con 130 controles sanos, con edades entre 2 y 15 años, que acudieron a consulta ambulatoria de rutina. Fueron comparadas variables demográficas, parto por cesárea, antecedentes familiares de alergias, tiempo de lactancia materna, exposición al humo de tabaco, mascotas, obesidad, porcentaje de eosinófilos y test de Helicobacter pylori positivo en heces con la presencia de enfermedades alérgicas como variable dependiente. Se utilizó: análisis bivariable y regresión logística binaria.
Resultados: Los factores asociados significativamente a enfermedades alérgicas fueron: antecedentes familiares de alergia, tiempo de lactancia materna menor a 12 meses, y test de Helicobacter pylori positivo en heces. Fueron identificados como predictores independientes asociados a enfermedades alérgicas: antecedentes familiares de alergia (RO=2,345; IC95%: 1,245 – 4,416; p = 0,008) y test de Helicobacter pylori positivo en heces (RO=2,072; IC95%: 1,090 – 3,939; p = 0,026).
Conclusión: La presencia de antecedentes familiares de alergia y test de Helicobacter pylori positivo en heces fueron identificados como variables independientes asociadas a enfermedades alérgicas.
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Bateman ED, Hurd S, Barnes P, Bousquet J, Drazen J, FitzGerald JM, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2018; 51(2). doi: 10.1183/13993003.51387-2007.
Charpin D, Ramadour M, Lavaud F, Raherison C, Caillaud D, de Blay F, et al. Climate and allergic sensitization to airborne allergens in the general population: data from the French Six Cities Study. Int Arch Allergy Immunol. 2017; 172: 236-241. doi: 10.1159/000471511
Kim BJ, Lee SY, Kim HB, Lee E, Hong SJ. Environmental changes, microbiota, and allergic diseases. Allergy Asthma Immunol Res. 2014; 6 (5): 389-400.
Liu Z, Xie L, Liu X, Chen J, Zhou Y, Zhang J, et al. Cesarean section and the risk of allergic rhinitis in children: a systematic review and meta-analysis. Sci Rep. 2023; 13:18361. doi: 10.1038/s41598-023-44932
Acevedo C. Influencia de la lactancia materna en el desarrollo de rinitis alérgica en niños. Ciencia e Innovación en Salud. 2022; e148: 51-64. doi: 10.17081/innosa.148
Saito-Abe M, Yamamoto-Hanada K, Pak K, Iwamoto S, Sato M, Miyaji Y, et al. How a Family History of Allergic Diseases Influences Food Allergy in Children: The Japan Environment and Children's Study. Nutrients. 2022; 14(20):4323. doi:10.3390/nu14204323
Daugule I, Zavoronkova J, Santare D. Helicobacter pylori and allergy: Update of research. World J Methodol 2015; 5(4): 203-211. doi: 10.5662/wjm.v5.i4.203
Albataineh E, Alnawaiseh N, Al-Zayadneh E, Al-amer R, Kaplan N, Abu-lobbad M. The Relationship between Helicobacter pylori (H. pylori) and Atopy and Allergic Diseases. Jordan J. Biol. Sci. 2018; 2(11):123-128.
Wang Y, Bi Y, Zhang L, Wang C. Is Helicobacter pylori infection associated with asthma risk? A meta-analysis based on 770 cases and 785 controls. Int J Med Sci. 2012; 9: 603-610. doi: 10.7150/ijms.4970
Ness-Jensen E, Langhammer A, Hveem K, Lu Y. Helicobacter pylori in relation to asthma and allergy modified by abdominal obesity: The HUNT study in Norway. World Allergy Organ J. 2019; 12(5):100035. doi: 10.1016/j.waojou.2019.100035
Zuo ZT, Ma Y, Sun Y, Bai CQ, Ling CH, Yuan FL. The Protective Effects of Helicobacter pylori Infection on Allergic Asthma. Int Arch Allergy Immunol. 2021; 182(1):53-64. doi:10.1159/000508330
Global initiative for asthma - GINA [Internet]. Global Initiative for Asthma - GINA. 2016 [citado 2023 may 30]. Disponible en: http://www.ginasthma.org
Leung DY, Hanifin JM, Charlesworth EN, Li JT, Bernstein IL, Berger WE, et al. Disease management of atopic dermatitis: a practice parameter. Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology. Work Group on Atopic Dermatitis. Ann Allergy Asthma Immunol. 1997; 79(3):197-211. doi:10.1016/s1081-1206(10)63003-7
Kassisse EII, Surga Félix J, Torres Bermúdez J, Kassisse JE. Prevalencia de las enfermedades alérgicas en niños parasitados. Reporte negativo de causalidad. Rev Pediatr Aten Primaria. 2020; 22:e111-e119.
Wang D, Chen Y, Ding Y, Tu J. Inverse association between Helicobacter pylori infection and childhood asthma in a physical examination population: a cross-sectional study in Chongqing, China. BMC Pediatr. 2022; 22(1):615. doi: 10.1186/s12887-022-03682-8
Lionetti E, Leonardi S, Lanzafame A, Garozzo MT, Filippelli M, Tomarchio S, et al. Helicobacter pylori infection and atopic diseases: Is there a relationship? A systematic review and meta-analysis. World J Gastroenterol 2014; 20(46):17635-17647. DOI: 10.3748/wjg.v20.i46.17635
Serrano CA, Talesnik E, Peña A. Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-β. European Journal of Gastroenterology & Hepatology. 2011; 23(8):656-663. doi: 10.1097/meg.0b013e328347c231
Tsigalou C, Konstantinidis TG, Cassimos D, Karvelas A, Grapsa A, Tsalkidis A, Panopoulou M, Tsakris A. Inverse association between Helicobacter pylori infection and childhood asthma in Greece: a case-control study. Germs. 2019; 9(4):182-187. doi: 10.18683/germs.2019.1174
Daugule I, Karklina D, Remberga S, Rumba-Rozenfelde I. Helicobacter pylori Infection and Risk Factors in Relation to Allergy in Children. Pediatr Gastroenterol Hepatol Nutr. 2017; 20(4):216-221. doi:10.5223/pghn.2017.20.4.216
Corrado G, Luzzi I, Pacchiarotti C, Lucarelli S, Frediani T, Cavaliere M, Rea P, Cardi E. Helicobacter pylori seropositivity in children with atopic dermatitis as sole manifestation of food allergy. Pediatr Allergy Immunol 2000; 11:101-105. doi: 10.1034/j.1399-3038.2000.00028.x
Harris PR, Smythies LE, Smith PD, Perez-Perez GI. Role of childhood infection in the sequelae of H. pylori disease. Gut Microbes. 2013; 4:426-438. doi: 10.4161/gmic.26943
Bakos N, Fekete B, Prohászka Z, Füst G, Kalaby L. High prevalence of IgG and IgA antibodies to 19-kDa Helicobacter pylori-associated lipoprotein in chronic urticaria. Allergy. 2003; 58: 663-7. doi: 10.1034/j.1398-9995.2003.00200.x
Tan RJ, Sun HQ, Zhang W. A 21-35 kDa mixed protein component from Helicobacter pylori activates mast cells effectively in chronic spontaneous urticaria. Helicobacter. 2016; 21(6): 565–574. doi: 10.1111/hel.12312
Cremonini F, Gasbarrini A. Atopy, Helicobacter pylori and hygiene hypothesis. Eur J Gastroenterol Hepatol. 2003; 15:635-636. doi: 10.1097/00042737-200306000-00009
Romagnani S. The role of lymphocytes in allergic disease. J Allergy Clin Immunol. 2000; 105: 399-408. doi: 10.1067/mai.2000.104575
Christiansen ES, Kjaer HF, Eller E, Bindslev-Jensen C, Host A, Mortz CG, et al. Early childhood risk factors for rhinoconjunctivitis in adolescence: a prospective birth cohort study. Clin Transl Allergy. 2017; 7:9. doi: 10.1186/s13601-017-0147-x
Bolat E, Arikoglu T, Sungur MA, Batmaz SB, Kuyucu S. Prevalence and risk factors for wheezing and allergic diseases in preschool children: a perspective from the Mediterranean coast of Turkey. Allergol Immunopathol. 2017; 45: 362–368. doi: 10.1016/j.aller.2017.01.002
llemar V, Magnusson PK, Lundholm C, Zettergren A, Melén E, Lichtenstein P, et al. Heritability and confirmation of genetic association studies for childhood asthma in twins. Allergy. 2016; 71:230–238. doi: 10.1111/all.12783
Forno E, Wang T, Yan Q, Brehm J, Acosta-Perez E, Colon-Semidey A, et al. A multiomics approach to identify genes associated with childhood asthma risk and morbidity. Am J Respir Cell Mol Biol. 2017; 57:439-447. doi: 10.1165/rcmb.2017-0002OC
Wu LS, Sjakste T, Sakalauskas R, Sitkauskiene B, Paramonova N, Gasiuniene E, et al. The burden of allergic asthma in children: a landscape comparison based on data from Lithuanian, Latvian, and Taiwanese populations. Pediatr Neonatol. 2012; 53:276–282. doi: 10.1016/j.pedneo.2012.08.001
Hatakka K, Piirainen L, Pohjavuori S, Poussa T, Savilahti E, Korpela R. Allergy in day care children: prevalence and environmental risk factors. Acta Paediatr. 2009; 98(5):817-22. doi: 10.1111/j.1651-2227.2008.01198.x
Snijders BE, Damoiseaux JG, Penders J, Kummeling I, Stelma FF, Van RR, et al. Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study). Clin Exp Allergy. 2006; 36(12):1609-15. doi: 10.1111/j.1365-2222.2006.02613.x
Bion V, Lockett GA, Soto-Ramírez N, Zhang H, Venter C, Karmaus W, et al. Evaluating the efficacy of breastfeeding guidelines on long-term outcomes for allergic disease. Allergy. 2016; 71(5): 661–70. doi: 10.1111/all.12833
Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, et al. Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review. Am J Clin Nutr. 2019; 109(Supplement_7):772S-799S. doi: 10.1093/ajcn/nqy283
Jelding-Dannemand E, Malby Schoos A-M, Bisgaard H. Breast-feeding does not protect against allergic sensitization in early childhood and allergy-associated disease at age 7 years. J Allergy Clin Immunol. 2015; 136(5): 1302-8. e-1–13. doi: 10.1016/j.jaci.2015.02.023
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